
Coway
Airmega AP-1512HH Mighty
Durable, effective for allergens/odors, but loud on high.

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Do you know the exact substances causing your symptoms? I ask because purifiers are generally good at removing particulates **or** removing gases/vapors/odors/VOCs, but not both. I'll cover particulates purifiers. I assume your definition of "True" HEPA is ≥99.97% efficiency at 0.3 microns from the U.S. Department of Energy DOE-STD-3020-2015 standard. There's also a European standard, [EN 1822-1:2019 High efficiency air filters (EPA, HEPA and ULPA)](https://www.airum.com/frontend/immagini/files/EN%201822-1.PDF). This has two HEPA filter classes, H13 (≥99.95% efficiency at MPPS) and H14 (≥99.995% efficiency at MPPS). Something serious for someone in your position would likely be the [**IQAir Cleanroom H13**](https://www.iqair.com/products/air-purifiers/cleanroom-h13). It uses a [PreMax Pre-filter (F8 XL)](https://www.iqair.com/products/replacement-filters/premax-pre-filter-f8-xl-f1) with a surface area of 75 sq. ft. and a [HyperHEPA H13 (XL) filter](https://www.iqair.com/products/replacement-filters/hyperhepa-h13-filter-f2) with a surface area of 81 sq. ft. Combined surface area is 156 sq. ft. Both filters have an antimicrobial treatment. The HyperHEPA H13 (XL) filter claims to be leak tested. The purifier and its filters are designed to *not* off gas. Unfortunately this is all very expensive in terms of initial and ongoing costs. In general, IQAir models are [loud on the highest airflow speeds](https://cms.iqair.com/sites/default/files/documents/Tech%20Specs_CR%20H13%20NE_120V_130723.pdf). This is a problem because you'll get the fastest air cleaning on these speeds. The Cleanroom H13 doesn't come with wheels or casters; you'll need to purchase the [Mobility 56](https://www.iqair.com/products/accessories-replacement-parts/mobility-56) kit. Alternatively, you may want to consider *two* [**IQAir HealthPro Compact XE**](https://www.iqair.com/products/air-purifiers/healthpro-compact-air-purifier?Model=XE) purifiers instead. This model has casters. Other advice: reduce coarse (visible) dust particles as much as possible. We have a list of strategies from our FAQs wiki page entry ["What else can I do to reduce dust?"](https://www.reddit.com/r/AirPurifiers/wiki/index/faqs/#wiki_what_else_can_i_do_to_reduce_dust.3F). If those don't suffice, you may want to consider adding the [IQAir PF40 kit](https://www.iqair.com/products/accessories-replacement-parts/pf40-kit) to any compatible IQAir purifiers you buy. A PF40 kit will reduce airflow to some extent. Only one Cleanroom H13 for 700 sq. ft. may not be enough even on the top airflow speed. Two HealthPro Compact XEs should be enough on the top airflow speeds. There are other much quieter air purifiers with high particulate CADRs like the [Coway Airmega ProX](https://cowaymega.com/products/airmega-prox) and the [Smart Air Blast MKII](https://www.smarterhepa.com/products/smart-air-blast). The Airmega ProX is a quality machine and it has wheels, but there are issues with Coway's filters potentially off gassing. Its top Smoke CADR is 568 CFM. The Smart Air Blast MKII has a top composite CADR of 559 CFM. It has wheels and a powder-coated steel housing. I haven't read stories about the filter off gassing, but it's possible. The Blast's HEPA filter has 150 sq. ft. of area. There is quite a bit of dirty air bypassing filter given the disparity between the CADRs and raw airflows. Regarding gaseous pollutants, these are far trickier to remediate as you need many pounds of activated carbon or other sorbent media. Depending on the gases present, modified sorbents may be needed.
Most consumer level air purifiers aren't usually built with odor/fumes in mind. They may come with activated charcoal filter but they're thin or gets saturated quickly which needs to be changed often depending on how fast the adsorption is. Thicker carbon filters are found in more expensive commercial/industrial multi-stage air scrubbers. So you're looking at spending at least $650 or more for brands like AirDoctor and over $1,000 for the IQAir (Swiss) with very thick carbon filter.
IQAir. Austin Air is another brand worthy of looking into and Doctor Air. We use three IQAir at the cat rescue I volunteer and it's amazing how much smell it captures even with litterbox everywhere with up to 30 cats in the facility.
We have the IQAir HealthPro. We do vacuum the bottom pre-filter twice a day because of the cats...
IQAir is definitely up there along with Austin Air. DoctorAir is another. Austin Air uses solid stainless steel for their housing. IQAir is mostly plastic like DoctorAir. But if you want the most odor/fume capture, IQAir and Austin Air would be my go to. Just know their filters are not cheap.
If you are willing to spend the money, I probably won't look further than IQAir that's rated one of the best. But they are at least $1,000 per unit and filters are not cheap for their three stage. But it's hospital grade and will tackle everything from fine dust to odor. Carbon filter is what capture both fume and odor. The only thing I'm not sure as I'm no professional is how much it'll filter and capture radioactive material. HEPA will capture fine particles up to 0.3 microns but there's ULPA filter that's rated above HEPA to capture 0.13 microns. Another comparable brand that's less expensive would be AirDoctor air purifiers. They're also certified like IQAir and is of quality. For 2,200 sq/ft home, you're likely looking at two units; one in the living room and one in the master bedroom, for example. If we were talking general dust and pollen, there are plenty of inexpensive HEPA filter system like Winix and Coway but if you're dealing with more serious particulates as well as odor then I'd consider IQAir or AirDoctor.
IQAIR is the answer, what I love is that I can take the whole thing apart and wipe every surface clean between filter changes. I think that helps a lot with keeping it clean.
IQAir. Have had the same one for 6 years now
An IQ air HealthPro 250 XE is considerably better for the same price, but of course, it's quite ugly; they've had the same design for 30 years. Another option would be a Coway Airmega 450, but I personally don't like the treated green filters they use.
I’ve had air purifiers around my reptiles for a few years and I’ve had no problems. Air purifiers just clean things from the air and make it cleaner so I don’t think there’s much risk for reptiles? I’d wait for other replies to see what other people have found. The ones I use are Honeywell and the HealthPro, given I use them for health reasons and not for my pets. But I’ve never had any problems

Coway
Airmega AP-1512HH Mighty
Durable, effective for allergens/odors, but loud on high.

Levoit
Vital 200S-P
Smart, effective dust/odor; some find replacement filters pricey.

Winix
5500-2
Budget king, durable; poor VOC removal, Plasmawave disliked.

Coway
Airmega Mighty
Durable, great for allergies/dust, responsive auto-fan.

Winix
5510 & 5520
Good value, durable, effective for pets; carbon filter issues.

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IKEA - UPPÅTVIND

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CleanAirKits - Corsi-Rosenthal Box

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Austin Air - Healthmate Plus

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Winix - 5500-2

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Coway - Airmega 400

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Coway - Airmega AP-1512HH Mighty